Metabolic Infrastructure of Pregnant Women with Fetuses Having Nervous System Abnormalities; Metabolomic Analysis

Central nervous system diseases are neurological disorders that affect the structure or function of brain and spinal cord make up central system. In this study, it was aimed to examine impaired/altered metabolomic profiles pregnant women carrying fetuses with abnormalities (NSA). The study group consisted 30 normal pregnancies (control group) 8 having NSA (study group), as determined by prenatal screening diagnosis part an antenatal care program. Metabolomic analyses were carried out using gas chromatography-mass spectrometry (GC-MS). GC-MS-based metabolomics analysis able identify 95 metabolites 27 them statistically significant between two groups (p<0.05). Moreover, pathway analysis, performed significantly altered metabolites, showed alteration in alanine, aspartate, glutamate metabolism, citrate cycle, aminoacyl t-RNA biosynthesis, glutathione metabolism. Alanine, aspartate metabolism seem be critical NSAs. However, abnormality-specific studies necessary for further recommendations.